Oxandrolone, which goes by the brand name Anavar was first produced in 1964 at the Searle laboratory, now known as Pfizer.
It was originally designed for the treatment of anemia, osteoporosis and hereditary angioedema.
This steroid was also used in the building of muscle mass in patients that have lost weight due to severe infections and other medical conditions associated with muscle wasting.
Oxandrolone is a mild anabolic steroid that has been safely used in the treatment of children, women and men.
Body builders and other individual who are into competitive sports recognizes the great benefits of Anavar in producing the quality of muscle they required in competition and have relied on Anavar to build lean muscle mass, cut down fat and improve performance.
This led to the great popularity of this steroid. Click here to buy legal Anavar online, without a prescription.
Opinions of many including the FDA and many other sporting authorities changed as the abuse of Anavar rose years after it was first produced.
Restrictions were placed by the FDA on the use of this steroid in the early 80s and it was removed from the shelves in the United States in 1989.
Many sporting authorities also restricted participants from the use of the steroid as performance enhancers. Manufacturing of the steroid was discontinued as Oxandrolone disappeared from pharmacies in the United State.
This wind blew across many countries as restrictions were placed on the production and use of this anabolic steroid.
However, with the recent discovery of the usefulness of Oxandrolone in the treatment of HIV/AIDS relating wasting syndrome, the production of Oxandrolone was commenced again and today is found and sold in the United States bearing the brand name Oxandrin.
Bio-Technology General (BTG) purchased the rights to produce the drug and now manufactures Oxandrin.
Today this steroids is produced in the US and other countries and sold solely for the purpose of medical treatment.
Oxandrolone, also known as Anavar is a derivative of dihydrotestosterone.
This steroid exhibits reasonable level of anabolic properties and a low level of androgenic effects.
This reduced level of androgenicity can be attributed to the fact that Oxandrolone lacks the capacity to interact with 5-alpha reduction enzyme.
Oxandrolone does not have the same potential as testosterone which is a more powerful androgenic compound.
An important property of Oxandrolone is that it does not aromatize. Thus, it does not convert to estrogen.
The implication of this is the promotion of linear growth without water retention.
This property appears to be very important to body builders. The drug is tolerated by men and women at reasonable doses.
Owing to the fact that Oxandrolone does not aromatize and convert to estrogen at low doses, it hardly interferes with the natural production of testosterone.
However, at higher doses the suppression of the natural production of testosterone is may occur.
This is typical of other anabolic / androgenic steroid. HPTA is usually restored through a post cycle therapy.
The use of Clomid/Novaldex or HCG is usually not necessary when Oxandrolone is used alone at a low dose.
Studies done on Anavar show that low doses interfere only minimally with the body’s ability to produce testosterone naturally.
Also, provided Anavar is used in low doses as a standalone steroid, there is no need to add other drugs such as Clomid to counteract side effect.
This is mainly because Anavar does not convert to estrogen, which has an intense effect on hormone production.
With no estrogen to interfere with other hormones, it takes a great deal more of the drug to cause side effects.
However Anavar can still interfere with the natural production of testosterone, especially at high doses.
Although estrogen is a vital part of this process, but it is apparent that the androgenic action of these steroids can also trigger inhibition.
When it comes to the typical bodybuilders using Anavar to increase growth, it would be expected that sustaining normal testosterone production would also present a challenge.
Oxandrolone is a 17 alpha alkylated steroid, which means it is formulated to pass through the liver without being changed by metabolic processes.
While this makes it easy to take, it also causes added stress to the liver. In spite of this, Anavar is quite mild on the liver and generally well-tolerated.
Though liver enzymes may sometimes be elevated, actual liver damage from Oxandrolone is very unusual at recommended doses.
Health care company Bio-Technology General has asserted that Anavar is not as fully metabolized as other 17aa steroids, as proven by the fact that about 30% of the drug is excreted by the urine fully intact.
This could be because it is so much milder and less hepatotoxic than similar steroids.
This was the result of a study that compared Oxandrolone such substances as norethandrolone, methyltestosterone, fluoxymesterone and methAndriol.
This study proved that Anavar causes the lowest markers of liver stress of all the oral steroids tested.
20mg of Anavar produced 72% lower levels of the markers examined than the same dose of fluoxymesterone. This is significant because both substances are altered in the same way.
These findings added to the experience of many athletes who report having no problems with the drug lead many people to feel more comfortable with using the drug than most other oral steroids.
While it may be true that the potential for liver damage from Oxandrolone is minimal, the potential is still there and cannot be ignored.
Anavar is very popular among body builders, weight lifter and athletes for many reasons, among these reasons includes its ability to promote muscle strength and endurance.
It also produces decent muscle gains without water retention. Anavar brings about tremendous muscle recovery and enhances fat loss.
These benefits are produced as Anavar is used at adequate dosage along with proper diets and trainings.
It is commonly used in the cutting phase of training, where the prevention of water retention is important.
It is not ideal for the bulking phase.
Interestingly, this steroid is used and tolerated by many women.
Androgenic effects that accompany the use of many anabolic steroids are greatly reduced among women who use this steroid.
For women a daily dosage of 5mg is enough to produce reasonable growth with little or no androgenic effects.
However, slight androgenic effect may be experienced.
The recommended dosage of Anavar is 20-80mg daily. This dose produces decent growth with little effects.
However, better results are obtained as Anavar is stacked or combined with other anabolic steroid such as; Trenbolan and Durabolin produces good results when used with Anavar and harder muscles are produced without water retention.
The addition of a potent non aromatizing androgens such as Trenbolone, Proviron or Halotestin also improves the hardness of muscles and gives the individual a more masculine physique.
This combination have also been found effective in the reduction of visceral and subcutaneous fat especially those around the abdomen and thigh.
Oxandrolone forms part of some stack and one of such is the addition of Anavar to bulking stack. Here testosterone or Dianabol is stacked with anavar.
This combination is used by some athlete. Oxandrolone produces some unfavorable effects on the lipid profile especially when used at high dosage.
Anavar has the capability of lowering the cholesterol and triglyceride level.
This action is quite unfavorable to the liver because it alters the HDL and LDL balance of the body.
The use of Anavar promotes the fall in good cholesterol (HDL) and enhances the rise of bad cholesterol (LDL).
This has the tendency of increasing the chances of occurrence of atherosclerosis, high blood pressure and in severe cases cardiac disease.
Of course, this occurs when Oxandrolone steroids are taken in high doses and prolonged period.
Common mild effects of the use of anavar are acne, oily skin and male pattern hair loss which is seen in individuals that are already predisposed to the condition.